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Non-linearities in the pharmacokinetics of di-(2-ethylhexyl) phthalate and metabolites in male rats

✍ Scribed by Per Sjöberg; Ulf Bondesson; Margareta Hammarlund

Publisher
Springer-Verlag
Year
1985
Tongue
English
Weight
524 KB
Volume
58
Category
Article
ISSN
0340-5761

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✍ Putman, D. L. ;Moore, W. A. ;Schechtman, L. M. ;Hodgson, J. R. 📂 Article 📅 1983 🏛 Wiley (John Wiley & Sons) ⚖ 283 KB 👁 1 views

Di-(2-ethylhexyl)phthalate (DEHP) and its two major metabolites, mono-(2-ethyl-hexy1)phthalate (MEHP) and 2-ethylhexanol (EH), were evaluated for their ability to induce chromosomal damage in male Fischer 344 rats after oral administration. Dose levels, the highest of which represents one-tenth of t