Polyamines are essential in various biological systems such as cellular proliferation including tumor growth, differentiation and neoplastic transformation including carcinogenesis. ␣-Difluoromethylornithine (DFMO) is a specific irreversible inhibitor of ornithine decarboxylase, a key enzyme in poly
✦ LIBER ✦
Non-linear model of cancer growth and metastasis: a limiting nutrient as a major determinant of tumor shape and diffusion
✍ Scribed by G.P. Pescarmona; M. Scalerandi; P.P. Delsanto; C.A. Condat
- Book ID
- 117839856
- Publisher
- Elsevier Science
- Year
- 1999
- Tongue
- English
- Weight
- 391 KB
- Volume
- 53
- Category
- Article
- ISSN
- 0306-9877
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## Abstract Antibiotic forms of tetracycline exhibit antitumor activity in some tumor models. However, their low __in vivo__ efficacy and associated morbidity limit their long‐term application in cancer therapy. This report appraises the efficacy of doxycycline (DC) and non‐antimicrobial, chemicall