✦ LIBER ✦
Non-linear effects operate and dynamic ligand exchange occurs when chiral BINOL–boron Lewis acids are used for asymmetric catalysis
✍ Scribed by Jean Philippe Cros; Yolanda Pérez-Fuertes; Michael J Thatcher; Susumu Arimori; Steven D Bull; Tony D James
- Book ID
- 104359879
- Publisher
- Elsevier Science
- Year
- 2003
- Tongue
- English
- Weight
- 157 KB
- Volume
- 14
- Category
- Article
- ISSN
- 0957-4166
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✦ Synopsis
Non-linear effects reveal that the use of chiral BINOL-boron reagents for aza-Diels-Alder reactions results in an enantioselective catalytic species containing at least 2 equiv. of BINOL. Dynamic ligand exchange and ligand accelerated catalysis occurs in these reactions, consistent with the formation of a cyclic borate ester of BINOL with enhanced Lewis acidity.