Non-invasive real-time flux sensors

• Book ID: 101722131
• Publisher: John Wiley and Sons
• Year: 2009
• Tongue: English
• Weight: 42 KB
• Volume: 102
• Category: Article
• ISSN: 0006-3592
• DOI: 10.1002/bit.22228

✦ Synopsis

In addition to ongoing research aimed at enhancing sensor performance (e.g., sensitivity, selectivity, response time), research over the last few decades has focused on the development of novel sensing modalities (e.g., lab-on-a-chip devices and bioassays). The self-referencing technique is a proven sensing modality used in neurobiology, plant physiology, and marine invertebrate physiological applications. Self-referencing converts static concentration sensors into dynamic analyte flux sensors for real-time, noninvasive characterization of active biological transport. McLamore, Porterfield, and Banks introduce the self-referencing sensing modality to the field of biofilm physiology. A reversible enzyme inhibition study was conducted on an environmental biofilm to demonstrate the types of attainable signals lost to signal noise using traditional (non-oscillating) sensing techniques. Use of this sensing modality will advance our understanding of fundamental phenomena concerning chemical toxicity exposure, biodegradation of hazardous compounds, and biocorrosion in biofilm systems.