Non-invasive product temperature determination during primary drying using tunable diode laser absorption spectroscopy

Rapid determination of vial heat transfe

Rapid determination of vial heat transfer parameters using tunable diode laser absorption spectroscopy (TDLAS) in response to step-changes in pressure set-point during freeze-drying

✍ Wei Y. Kuu; Steven L. Nail; Gregory Sacha 📂 Article 📅 2009 🏛 John Wiley and Sons 🌐 English ⚖ 360 KB

The purpose of this study was to perform a rapid determination of vial heat transfer parameters, that is, the contact parameter K(cs) and the separation distance l(v), using the sublimation rate profiles measured by tunable diode laser absorption spectroscopy (TDLAS). In this study, each size of via