✦ LIBER ✦

Non-Hydrolyzable RNA–Peptide Conjugates: A Powerful Advance in the Synthesis of Mimics for 3′-Peptidyl tRNA Termini

✍ Scribed by Holger Moroder; Jessica Steger; Dagmar Graber; Katja Fauster; Krista Trappl; Viter Marquez; Norbert Polacek; Daniel N. Wilson; Ronald Micura

Book ID: 102728290
Publisher: John Wiley and Sons
Year: 2009
Tongue: English
Weight: 556 KB
Volume: 48
Category: Article
ISSN: 0044-8249
DOI: 10.1002/anie.200900939

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

Translation of specific small peptides on the ribosome can confer resistance to macrolide antibiotics. To reveal the molecular details of this and related phenomena, stable RNA–peptide conjugates that mimic peptidyl‐tRNA would be desirable, especially for ribosome structural biology. A flexible solid‐phase synthesis strategy now allows efficient access to these highly requested derivatives without restriction on the RNA and peptide sequences.magnified image

📜 SIMILAR VOLUMES

Non-Hydrolyzable RNA–Peptide Conjugates:

Non-Hydrolyzable RNA–Peptide Conjugates: A Powerful Advance in the Synthesis of Mimics for 3′-Peptidyl tRNA Termini

✍ Holger Moroder; Jessica Steger; Dagmar Graber; Katja Fauster; Krista Trappl; Vit 📂 Article 📅 2009 🏛 John Wiley and Sons 🌐 English ⚖ 556 KB

## Abstract **Die Translation kleiner Peptide** am Ribosom kann diesem eine Resistenz gegen Macrolidantibiotika verleihen. Zur Aufklärung dieses und ähnlicher Phänomene sind stabile RNA‐Peptid‐Konjugate, die Peptidyl‐tRNA imitieren, wünschenswert, besonders für die strukturbiologische Untersuchung