Non-Hodgkin's lymphoma after liver transplantation: Response to chemotherapy

✍ Scribed by Gallego-Melcón, Soledad; Sánchez de Toledo, José; Martínez, Vicente; Moraga, Fernando; Iglesias, Juan; Ruiz, Carmen; Allende, Elena

• Publisher: John Wiley and Sons
• Year: 1996
• Tongue: English
• Weight: 445 KB
• Volume: 27
• Category: Article
• ISSN: 0098-1532
• DOI: 10.1002/(sici)1096-911x(199609)27:3<156::aid-mpo4>3.0.co;2-d

✦ Synopsis

An increased incidence of lymphoproliferative disorders in immunosuppressed organ transplant recipients has long been recognised. Lymphoproliferative disorders occur in 2% of orthotopic liver transplant patients. Different therapies have been used, but the optimal treatment remains unknown. Relatively little information is available on experiencewith cytotoxic chemotherapy. Three children who developed Burkitt-like, non-Hodgkin's lymphomas after liver transplantation are described. The disease failed to regress after initial management, which included a reduction in immunosuppression. With cytotoxic chemotherapy all three achieved complete remission, which continued 36+, 35+, and 1 6 f months after diagnosis. Results suggest that in selected cases chemotherapy can be safe in late-onset lymphomas appearing after solid organ transplantation.