Non-Conventional Synthesis: Bioactive Heterocycles

✍ Scribed by György Keglevich; Bubun Banerjee (editors)

• Publisher: De Gruyter
• Year: 2023
• Tongue: English
• Leaves: 584
• Series: Green Bioactive Heterocycles; 1
• Category: Library

✦ Synopsis

Non-conventional synthetic methods may provide new and green methods for the preparation of bioactive heterocycles. These methods, such as microwave and ultrasound assisted synthesis, biocatalysis, photochemistry and electrosynthesis use less energy and may produce less waste to get the desired products when compared to traditional methods. This book explores the use of these methods when synthesizing various biologically relevant heterocyclic scaffolds.

THE SERIES: GREEN BIOACTIVE HETEROCYCLES
Heterocycles are a widely utilized group of molecules as they often contain bioactivity that is useful in drug development, agriculture, and other applications. However, their synthesis remains challenging with diffi cult to control functional groups. With a greater focus on sustainable synthesis practices, there is a need to develop greener synthetic methods for the synthesis of structurally diverse bioactive heterocyclic scaffolds. This series aims to do so, by collecting developments into common themes.

Discusses untraditional synthesis methods for producing bioactive heterocycles.

Methods explored include the use of microwave, ultrasound, mechanochemistry, photochemistry, biocatalysis, click chemistry, and more.

✦ Table of Contents

Preface
Foreword
A brief professional profile of Prof. Anil Kumar Singh
Contents
List of contributors
Chapter 1 Microwave-assisted catalyst-free synthesis of bioactive heterocycles
Chapter 2 Microwave-assisted synthesis of N-heterocycles
Chapter 3 Microwave-assisted synthesis of O,S-heterocycles
Chapter 4 Ultrasound-assisted synthesis of N-heterocycles
Chapter 5 Ultrasound-assisted synthesis of O,S-heterocycles
Chapter 6 Ultrasound-assisted synthesis of bioactive 1,2,3-triazoles via click reactions
Chapter 7 Photoirradiated synthesis of bioactive heterocycles
Chapter 8 Synthesis of heterocycles through electrolysis
Chapter 9 Flow synthesis of oxygen and nitrogen heterocycles
Chapter 10 Ball-milling-promoted synthesis of bioactive heterocycles
Chapter 11 Synthesis of bioactive heterocycles via click reaction
Chapter 12 Synthesis of bioactive heterocycles by nanocatalysis
Chapter 13 Enantioselective metal-catalyzed domino reactions in the total synthesis of bioactive heterocycles
Chapter 14 Synthesis of pharmacologically significant pentathiepins: a journey from harsh to mild conditions
Chapter 15 Developments in the synthesis of ring phosphine oxides
Chapter 16 Total synthesis of bioactive heterocyclic scaffolds via Pauson Khand reaction
Chapter 17 Nonconventional approaches in drug discovery
Index