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Non-competitive N-methyl-D-aspartate antagonists protect against sound-induced seizures in DBA/2 mice

✍ Scribed by Astrid G. Chapman; Brian S. Meldrum


Book ID
115882102
Publisher
Elsevier Science
Year
1989
Tongue
English
Weight
786 KB
Volume
166
Category
Article
ISSN
0014-2999

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Primary cultures of embryonic cortical cells were used to test the neuroprotective effect of two novel noncompetitive N-methyl-D-aspartate antagonists against the neurotoxicity of glutamate. These two compounds, GK 11 and GK 222, are phencyclidine derivatives that contain asymetric carbon atoms. We