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Non-cell-autonomous effects of vector-expressed regulatory RNAs in mammalian heart cells

✍ Scribed by Kizana, E; Cingolani, E; Marbán, E


Book ID
109855321
Publisher
Nature Publishing Group
Year
2009
Tongue
English
Weight
580 KB
Volume
16
Category
Article
ISSN
0969-7128

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## Abstract Following CD80/86 (B7) and TLR9 ligation, small subsets of splenic dendritic cells expressing CD19 (CD19^+^ DC) acquire potent T cell regulatory functions due to induced expression of the intracellular enzyme indoleamine 2,3‐dioxygenase (IDO), which catabolizes tryptophan. In CD19^+^ DC