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Non-canonical kinase signaling by the death ligand TRAIL in cancer cells: discord in the death receptor family

✍ Scribed by Azijli, K; Weyhenmeyer, B; Peters, G J; de Jong, S; Kruyt, F A E

Book ID: 120189135
Publisher: Nature Publishing Group
Year: 2013
Tongue: English
Weight: 758 KB
Volume: 20
Category: Article
ISSN: 1350-9047
DOI: 10.1038/cdd.2013.28

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While TRAIL is relatively non-toxic to normal cells, it can selectively induce apoptosis in many types of transformed cells. Nevertheless, some non-small cell lung cancer (NSCLC) cells are particularly resistant to the effects of TRAIL. Here, we report that in combination with naringenin exposure to