## Background Phosphatidylinositol (PI) 3-kinase is activated by a variety of growth factor receptors and the PI 3-kinase/Akt signaling pathway is a key regulator of cell proliferation and survival. The downstream targets of PI 3-kinase/Akt signaling include direct regulators of cell cycle progress
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Non-canonical activation of Notch signaling/target genes in vertebrates
โ Scribed by Rajendran Sanalkumar; Sivadasan Bindu Dhanesh; Jackson James
- Publisher
- Springer
- Year
- 2010
- Tongue
- English
- Weight
- 467 KB
- Volume
- 67
- Category
- Article
- ISSN
- 1420-682X
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The STAT proteins (signal transducers and activators of transcription) are transcription factors mediating cytokine/growth factor signaling, which play important role in controlling cell cycle progression and apoptosis. In many cancer cell lines and tumors (including gliomas) the STAT proteins (in p