✦ LIBER ✦

Non-antigen signals for B-cell growth and differentiation to antibody secretion

✍ Scribed by Seth Lederman; Michael J. Yellin; Lori R. Covey; Aileen M. Cleary; Robin Callard; Leonard Chess

Publisher: Elsevier Science
Year: 1993
Tongue: English
Weight: 808 KB
Volume: 5
Category: Article
ISSN: 0952-7915
DOI: 10.1016/0952-7915(93)90066-2

No coin nor oath required. For personal study only.

✦ Synopsis

Recently, significant progress had been made in understanding the T-B lymphocyte interactions that control humoral immunity. This review highlights experiments that demonstrate a central role for interactions between T-cell-B-ceil-activating molecule (CD40 ligand) expressed on T cells and CD40 on B ceils in B-cell activation and immunoglobulin isotype switching, both in vitro and in vivo.

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