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Non-amine based analogs of lavendustin A as protein-tyrosine kinase inhibitors

โœ Scribed by Smyth, Mark S.; Stefanova, Irena; Hartmann, Frank; Horak, Ivan D.; Osherov, Nir; Levitzki, Alexander; Burke, Terrence R.


Book ID
125952353
Publisher
American Chemical Society
Year
1993
Tongue
English
Weight
626 KB
Volume
36
Category
Article
ISSN
0022-2623

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The synthesis and biological activity of a series of 5-[(2,5dihydroxybenzyl)amino]salicylic acid derivatives (3-6) as analogs of the active partial structure (2) of the potent EGF-R tyrosine kinase inhibitor lavendustin A (1) are described. Analogs with an electron-withdrawing group in place of the