Synthesis of deuterated vitamin B6 compo
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S. P. Coburn; C. C. Lin; W. E. Schaltenbrand; J. D. Mahuren
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Article
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1982
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John Wiley and Sons
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French
⚖ 525 KB
## Abstract 3‐Hydroxy‐4‐(hydroxymethyl)‐5‐(hydroxymethyl‐d~2~)‐2‐methylpyridine(pyridoxine‐d~2~) was prepared by reduction of α^4^‐3‐0‐isopropylidene‐5‐pyridoxic acid with lithium aluminum deuteride. Deuterium was inserted in the 2‐methyl group using base catalyzed exchange between deuterium oxide