Nodular malignant lymphomas. Factors affecting complete response rate and survival

✍ Scribed by Dr. Fernando Cabanillas; Gerald P. Bodey; Jordan U. Gutterman; Emil J. Freireich; Terry Smith

• Publisher: John Wiley and Sons
• Year: 1979
• Tongue: English
• Weight: 532 KB
• Volume: 44
• Category: Article
• ISSN: 0008-543X
• DOI: 10.1002/1097-0142(197912)44:6<1983::aid-cncr2820440604>3.0.co;2-4

✦ Synopsis

The records of 109 patients with non-Hodgkin's lymphoma of nodular pattern were reviewed to determine which factors were associated with a favorable response to therapy and prolonged survival. A logistic regression model was utilized to identify the pertinent variables. Prognostic factors associated with a favorable response were, in order of decreasing importance: treatment with an Adriamycin combination regimen, absence of bulky tumor, and no exposure to prior chemotherapy. Thos associated with prolonged survival were: normal hemoglobin level, treatment with an Adriamycin combination regimen, female sex, and no prior exposure to therapy. Achievement of complete remission in these disorders resulted in a statistically longer duration of survival compared to partial responses or failures. Patients whose complete remission was induced with an Adriamycin-containing regimen and maintained with BCG immunotherapy had a significantly longer complete remission than those who did not receive BCG. Knowledge of these factors can be important in planning and analyzing future therapeutic trials.