Nodular localized cutaneous amyloidosis: further demonstration of monoclonality of infiltrating plasma cells in four additional Japanese patients
✍ Scribed by Hagari; Mihara; Konohana; Ueki; Yamamoto; Koizumi
- Publisher
- John Wiley and Sons
- Year
- 1998
- Tongue
- English
- Weight
- 292 KB
- Volume
- 138
- Category
- Article
- ISSN
- 0007-0963
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✦ Synopsis
Nodular localized cutaneous amyloidosis (NLCA) is a disorder characterized by deposition of amyloid derived from immunoglobulin light chains. We used semi-nested polymerase chain reaction (PCR) to analyse archival paraffin-embedded sections from a previous patient and from four additional, previously reported patients with NLCA to determine whether involvement of monoclonal plasma cells is a universal feature of this condition. The semi-nested PCR analysis revealed one or two amplified bands, around 100-120 bp, for all five cases of NLCA, although the yields varied from case to case. These results suggest that clonal expansion of plasma cells in NLCA may occur locally.