Nocturnal body core temperature falls in Parkinson's disease but not in multiple-system atrophy

✍ Scribed by G. Pierangeli; F. Provini; P. Maltoni; G. Barletta; M. Contin; E. Lugaresi; P. Montagna; P. Cortelli

• Publisher: John Wiley and Sons
• Year: 2001
• Tongue: English
• Weight: 56 KB
• Volume: 16
• Category: Article
• ISSN: 0885-3185
• DOI: 10.1002/mds.1039

✦ Synopsis

Abstract

OBJECTIVE:

To evaluate whether the circadian rhythm of body core temperature (CRT°) can differentiate Multiple‐System Atrophy (MSA) from Idiopathic Parkinson's disease (IPD).

METHODS:

We evaluated 14 patients with probable MSA, seven with IPD, and eight controls. After a preliminary evaluation of cardiovascular autonomic function, rectal temperature and sleep‐wake cycle were monitored continuously for 48 hours in a temperature‐controlled room, at constant bed rest with controlled food intake and fixed light‐dark schedule.

RESULTS:

MSA patients showed cardiovascular autonomic sympathetic and parasympathetic failure. IPD had normal cardiovascular autonomic function. A 24‐hour rhythm of body core temperature (BcT°) was present in all subjects. IPD had CRT° comparable to controls. In MSA the mesor was higher and mean BcT° of each hour was significantly higher from 11 p.m. to 7 a.m. The analysis of mean BcT° during the different sleep phases showed significantly higher values during both NREM (1–2, 3–4) and REM sleep stages in MSA.

CONCLUSIONS:

The physiological nocturnal fall of BcT° is blunted in MSA patients mainly because BcT° did not decrease during sleep. This CRT° pattern is not justified by differences in sleep structure and may reflect an impairment of central sympathetic nervous system function. © 2001 Movement Disorder Society.