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Nociceptive Signals Induce Trafficking of TRPA1 to the Plasma Membrane

✍ Scribed by Manuela Schmidt; Adrienne E. Dubin; Matt J. Petrus; Taryn J. Earley; Ardem Patapoutian


Book ID
116783431
Publisher
Elsevier Science
Year
2009
Tongue
English
Weight
876 KB
Volume
64
Category
Article
ISSN
0896-6273

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## Abstract One pathological characteristic of Alzheimer's disease (AD) is extensive synapse loss. Presenilin 1 (PS1) is linked to the pathogenesis of early onset familial Alzheimer's disease (FAD) and is localized at the synapse, where it binds N‐cadherin and modulates its adhesive activity. To el