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Nociception and the differential expression of cyclooxygenase-1 (COX-1), the COX-1 variant retaining intron-1 (COX-1v), and COX-2 in mouse dorsal root ganglia (DRG)

✍ Scribed by Wenkai Dou; Yun Jiao; Sarita Goorha; Rajendra Raghow; Leslie R. Ballou


Book ID
113864875
Publisher
Elsevier Science
Year
2004
Tongue
English
Weight
453 KB
Volume
74
Category
Article
ISSN
0090-6980

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To study the possible role of the isoenzymes of cyclooxygenase COX-1 and COX-2 in the MPTP (1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine) mouse model of Parkinson's disease we used acetylsalicylic acid, a COX-1/COX-2 inhibitor, in comparison with meloxicam, a preferential COX-2 inhibitor. As markers