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Nociceptin/orphanin FQ receptor blockade attenuates MPTP-induced parkinsonism

โœ Scribed by Riccardo Viaro; Rosario Sanchez-Pernaute; Matteo Marti; Claudio Trapella; Ole Isacson; Michele Morari


Book ID
113812210
Publisher
Elsevier Science
Year
2008
Tongue
English
Weight
914 KB
Volume
30
Category
Article
ISSN
0969-9961

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The nociceptin/orphanin FQ (NOP) recepto
โœ Naomi P. Visanji; Rob M.A. de Bie; Tom H. Johnston; Andrew C. McCreary; Jonathan ๐Ÿ“‚ Article ๐Ÿ“… 2008 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 540 KB

## Abstract The antiโ€parkinsonian and levodopaโ€sparing potential of the nociceptin/orphanin FQ receptor (NOP) antagonist Jโ€113397 has been demonstrated in rodent models of Parkinson's disease. Here, we describe the levodopaโ€sparing potential of Jโ€113397 in MPTPโ€lesioned marmosets. Coadministration