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Nociceptin inhibits non-adrenergic non-cholinergic contraction in guinea-pig airway

✍ Scribed by S Shah; C P Page; D Spina


Book ID
110003836
Publisher
Nature Publishing Group
Year
1998
Tongue
English
Weight
277 KB
Volume
125
Category
Article
ISSN
0007-1188

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Several lines of evidence suggest a regulatory role for the non-adrenergic, non-cholinergic (NANC) nervous system in the airways of the guinea-pig and man. We examined NANC frequency-response characteristics (0.2-90 Hz) with respect to segmental differences and effects of cyclooxygenase-inhibition (

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GABA is a known inhibitory neurotransmitter in the CNS. Recent studies have also demonstrated the presence of GABA in peripheral tissue, including lung. To delineate a role for GABA in lung, the effect of GABA and selective GABA agonists and antagonists on neuronally-induced airway contractions in g