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Nobiletin improves hyperglycemia and insulin resistance in obese diabetic ob/ob mice

✍ Scribed by Young-Sil Lee; Byung-Yoon Cha; Kiyoto Saito; Hiroshi Yamakawa; Sun-Sil Choi; Kohji Yamaguchi; Takayuki Yonezawa; Toshiaki Teruya; Kazuo Nagai; Je-Tae Woo


Book ID
113489139
Publisher
Elsevier Science
Year
2010
Tongue
English
Weight
580 KB
Volume
79
Category
Article
ISSN
0006-2952

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Effect of metformin on hepatocyte insuli
✍ J. M. Lord; T. W. Atkins; C. J. Bailey πŸ“‚ Article πŸ“… 1983 πŸ› Springer 🌐 English βš– 575 KB

The effect of metformin on hepatocyte insulin receptor binding was examined in normal, streptozotocin diabetic and genetically obese diabetic (ob/ob) mice. In normal mice, chronic administration of metformin (60 mg X kg-1 X day-1 for 50 weeks) increased the number of low affinity receptors by 148%.