No trespassing: Ancient BST2 deletion confers protection against simian immunodeficiency virus infection of humans

Ancient origin of a deletion in human BS

Ancient origin of a deletion in human BST2/Tetherin that confers protection against viral zoonoses

✍ Daniel Sauter; Michael Vogl; Frank Kirchhoff 📂 Article 📅 2011 🏛 John Wiley and Sons 🌐 English ⚖ 219 KB

## Bone marrow stromal antigen 2 (BST2)/ Tetherin is an antiviral factor that blocks the release of enveloped virions from infected cells. Recent data suggest that efficient BST2 antagonism was a prerequisite for the global spread of HIV/AIDS. Most simian immunodeficiency viruses (SIVs), including