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No significant associations between two dopamine receptor polymorphisms and normal temperament

โœ Scribed by Jonathan Benjamin; Yamima Osher; R. H. Belmaker; Richard Ebstein

Publisher
John Wiley and Sons
Year
1998
Tongue
English
Weight
91 KB
Volume
13
Category
Article
ISSN
0885-6222

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โœฆ Synopsis

A replicated association has been reported between the normal personality trait of novelty seeking on the Tridimensional Personality Questionnaire (TPQ) and an exon III polymorphism in the dopamine D4 receptor gene (D4DR). Genotyping of a polymorphism in exon I of the same gene was carried out in 124 normal volunteers, and no association was found with any TPQ trait. In the same volunteers a dopamine D3 receptor gene (D3DR) point mutation in exon 1 was genotyped. Again, no overall association between any TPQ trait and alleles or genotype was found. There was a weak association between D3DR exon I genotype and harm avoidance in males only.

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