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No Role for Interleukin-18 in Acute Murine Stroke-Induced Brain Injury

✍ Scribed by Wheeler, Rachel D.; Boutin, Herve; Touzani, Omar; Luheshi, Giamal N.; Takeda, Kiyoshi; Rothwell, Nancy J.


Book ID
110088556
Publisher
Nature Publishing Group
Year
2003
Tongue
English
Weight
334 KB
Volume
23
Category
Article
ISSN
0271-678X

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Interleukin-18 (IL-18) is not only a co-stimulus for the induction of interferon-gamma but also has direct proinflammatory effects by inducing tumor necrosis factor-alpha (TNF-alpha), IL-1, IL-8 and IL-6. However, the cascade of events leading to induction of cytokines by IL-18 is unclear. The aim o