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No nonshivering thermogenesis in mice lacking UCP1, despite high UCP2 expression

✍ Scribed by B. Cannon; V. Golozoubova; A. Matthias; A. Jacobsson; J. Nedergaard


Book ID
114362347
Publisher
Elsevier Science
Year
2000
Tongue
English
Weight
80 KB
Volume
126
Category
Article
ISSN
1095-6433

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Fatty liver is vulnerable to conditions that challenge hepatocellular energy homeostasis. Lipidladen hepatocytes highly express uncoupling protein-2 (UCP2), a mitochondrial carrier that competes with adenosine triphosphate (ATP) synthesis by mediating proton leak. However, evidence for a link betwee