## Abstract Reports on Noonan syndrome (NS) have documented multiple types of coagulation defects and bleeding diathesis, and a wide range of clinical presentations. Early studies suggested that a large proportion of NS patients have coagulation defects, whereas more recent reports indicate low rat
✦ LIBER ✦
No mutation in the gene for Noonan syndrome, PTPN11, in 18 patients with Costello syndrome
✍ Scribed by Birte Tröger; Kerstin Kutsche; Hanno Bolz; Sabine Lüttgen; Andreas Gal; Zsuzsanna Almassy; Almuth Caliebe; Peter Freisinger; Elke Hobbiebrunken; Michel Morlot; Margarita Stefanova; Berthold Streubel; Dagmar Wieczorek; Peter Meinecke
- Publisher
- John Wiley and Sons
- Year
- 2003
- Tongue
- English
- Weight
- 42 KB
- Volume
- 121A
- Category
- Article
- ISSN
- 1552-4825
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## Abstract Noonan syndrome (NS) is an autosomal dominant disorder comprising short stature, facial dysmorphism, short and/or webbed neck, heart defects, and cryptorchidism in males. The gene responsible for the disorder (__PTPN11__) was recently identified, and explains 30–50% of the cases clinica
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