No increase of calcitonin gene–related peptide in jugular blood during migraine
✍ Scribed by Jesper Filtenborg Tvedskov; Kerstin Lipka; Messoud Ashina; Helle K. Iversen; Søren Schifter; Jes Olesen
- Publisher
- John Wiley and Sons
- Year
- 2005
- Tongue
- English
- Weight
- 106 KB
- Volume
- 58
- Category
- Article
- ISSN
- 0364-5134
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In normal human subjects (n = 6), blood flow in the common carotid artery, assessed with an ultrasonic duplex-scanning unit, was increased up to 152% of basal levels by 60-min infusions of human calcitonin gene-related peptide I (alpha CGRP) 80 pmol.kg-1.h-1, but it was not affected by 20 pmol.kg-1.
The expression and localization of the mRNA encoding the calcitonin gene-related peptide (CGRP) were analyzed in the rat facial nucleus after axotomy by Northern blot analysis and by in situ hybridization histochemistry (ISH) using a synthetic 32P-labeled oligonucleotide probe. Northern blot analysi