Recent reports have shown an association between an intronic polymorphism of the presenilin-1 (PSEN1) gene and late-onset (age at onset > 65) familial and sporadic (no family history) Alzheimer disease (AD). The reported association was independent of the effect of the only previously identified gen
No genetic association between the LRP receptor and sporadic or late-onset familial Alzheimer disease
β Scribed by William K. Scott; Larry H. Yamaoka; Meredyth P. Bass; P. Craig Gaskell; P. Michael Conneally; Gary W. Small; Lindsay A. Farrer; Sanford A. Auerbach; Ann M. Saunders; Allen D. Roses; J. L. Haines; Margaret A. Pericak-Vance
- Publisher
- Springer
- Year
- 1998
- Tongue
- English
- Weight
- 195 KB
- Volume
- 1
- Category
- Article
- ISSN
- 1364-6745
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Butyrylcholinesterase (BChE) as well as acetylcholinesterase has been suggested to be associated with Alzheimer's disease (AD). : Hum Mol Genet 6: 1933-1936] recently reported the synergism between the gene for the K variant of BChE (BCHE-K) and the 4 allele of apolipoprotein E (APOE 4) in late-onse
It is now commonly known that possession of one of the three common alleles of the apolipoprotein E (APOE) gene (allele epsilon 4) confers an increased risk for both familial and sporadic Alzheimer's disease (AD), and that this risk is dose-dependent. Other genes that may play a role in AD, either t