No evidence for an association between G protein β3 subunit gene C825T polymorphism and tardive dyskinesia in schizophrenia

✍ Scribed by Heon-Jeong Lee; Seung-Gul Kang; Jong-Woo Paik; Moon-Soo Lee; Bang-Hyun Cho; Young-Min Park; Won Kim; Jung-Eun Choi; In-Kwa Jung; Leen Kim; Min-Soo Lee

• Publisher: John Wiley and Sons
• Year: 2007
• Tongue: English
• Weight: 80 KB
• Volume: 22
• Category: Article
• ISSN: 0885-6222
• DOI: 10.1002/hup.875

✦ Synopsis

Abstract

Objective

Tardive dyskinesia (TD) is a long‐term adverse effect of antipsychotic. We evaluated candidate functional polymorphism of the G protein __β__3 subunit (GNB3) gene for association with drug‐induced TD in the Korean schizophrenic patients.

Methods

We investigated whether the C825T polymorphism of the GNB3 gene is associated with the TD in a Korean sample of schizophrenic patients with (n = 83) and without TD (n = 126), matched for antipsychotic drug exposure and other relevant variables.

Results

The distribution of genotypes and allele frequencies of GNB3 were not different between schizophrenic patients with TD and without TD (p > 0.05).

Conclusion

Within the limitations imposed by the size of the clinical sample, these findings suggest that the GNB3 825 C/T single nucleotide polymorphism (SNP) does not contribute significantly to risk for TD. Copyright © 2007 John Wiley & Sons, Ltd.