𝔖 Bobbio Scriptorium
✦   LIBER   ✦

No association of GSK3β gene (GSK3B) with Japanese schizophrenia

✍ Scribed by Masashi Ikeda; Nakao Iwata; Tatsuyo Suzuki; Tsuyoshi Kitajima; Yoshio Yamanouchi; Yoko Kinoshita; Norio Ozaki

Publisher
John Wiley and Sons
Year
2005
Tongue
English
Weight
64 KB
Volume
134B
Category
Article
ISSN
1552-4841

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

Several lines of evidence indicate that glycogen synthase kinase‐3β (GSK3β) is one of the candidates for schizophrenia‐susceptibility factor. However, it has not been reported the association analysis between GSK3β gene (GSK3B) and Japanese schizophrenia based on linkage disequilibrium (LD). We provide an association analysis using relatively large samples (381 schizophrenia, and 352 controls) after determination of “tag single nucleotide polymorphisms (SNPs).” In this LD mapping, we selected and genotyped for eight polymorphisms (seven SNPs and one diallelic (CAA)~n~ repeat), which covered the entire region of GSK3B, and determined two “tag SNPs.” In the following association analysis using these two “tag SNPs,” we could not find association with Japanese schizophrenia. Furthermore, we also include subgroup analysis considering age‐at‐onset and subtypes, neither could we find associations. Because our samples provided quite high power, these results indicate that GSK3B may not play a major role in Japanese schizophrenia. © 2005 Wiley‐Liss, Inc.

📜 SIMILAR VOLUMES

Crossregulation of NF-κB by the APC/GSK-
Crossregulation of NF-κB by the APC/GSK-3β/β-catenin pathway
✍ Jiong Deng; Weiya Xia; Stephanie A. Miller; Yong Wen; Hong-Ying Wang; Mien-Chie 📂 Article 📅 2004 🏛 John Wiley and Sons 🌐 English ⚖ 322 KB

## Abstract Glycogen synthase kinase‐3β (GSK‐3β) and adenomatous polyposis coli (APC) play an important role in the regulation of β‐catenin. Inhibition of or defects in their functions can lead to activation of β‐catenin. β‐catenin has been recently found to interact with and inhibit nuclear factor

Inhibition of GSK-3β decreases NF-κB-dep
Inhibition of GSK-3β decreases NF-κB-dependent gene expression and impairs the rat liver regeneration
✍ Huan Chen; Shengsheng Yang; Zhifeng Yang; Li Ma; Dandan Jiang; Jifang Mao; Bingh 📂 Article 📅 2007 🏛 John Wiley and Sons 🌐 English ⚖ 226 KB

## Abstract Serine‐threonine protein kinase glycogen synthase kinase (GSK)‐3 is involved in regulation of many cell functions, but its role in regulating liver regeneration is unknown. Here we investigated the effects of GSK‐3β inhibition on liver regeneration after partial hepatectomy in the rat.