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No association between allelic variants of HOXA1/HOXB1 and autism

✍ Scribed by Gallagher, Louise ;Hawi, Ziarih ;Kearney, Geraldine ;Fitzgerald, Michael ;Gill, Michael

Publisher: John Wiley and Sons
Year: 2003
Tongue: English
Weight: 64 KB
Volume: 124B
Category: Article
ISSN: 0148-7299
DOI: 10.1002/ajmg.b.20094

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

Two recent studies have reported conflicting findings of association of a variant in the HOXA1 gene and autism. To try to resolve the conflict in findings, we conducted an association study in 78 Irish families of the reported DNA variants. We did not find statistically significant association between the variants and autism. Similarly there was no evidence of preferential transmission of variants from parent of either sex to affected offspring. We also report negative findings for HOXB1 variants. We conclude that the HOXA1/B1 are unlikely to be the susceptibility genes for autism in our sample. © 2003 Wiley‐Liss, Inc.

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