N,N-Diisopropyl-N-phosphonyl imines lead to efficient asymmetric synthesis of aziridine-2-carboxylic esters
β Scribed by Kattamuri, Padmanabha V.; Xiong, Yiwen; Pan, Yi; Li, Guigen
- Book ID
- 120054374
- Publisher
- Royal Society of Chemistry
- Year
- 2013
- Tongue
- English
- Weight
- 629 KB
- Volume
- 11
- Category
- Article
- ISSN
- 1477-0520
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Chiral N-phosphonyl imines attached by 1-naphthyl group were found to react with lithium malonate enolates smoothly to give chiral b-aminomalonates. Good yields and excellent diastereoselectivity were achieved for sixteen examples. The chiral auxiliary can be readily removed by treating with trifluo