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N,N′-Dichlorobis(2,4,6-trichlorophenyl)urea (CC-2) as a new reagent for the synthesis of pyrimidone and pyrimidine derivatives via Biginelli reaction

✍ Scribed by G.B. Dharma Rao; B.N. Acharya; S.K. Verma; M.P. Kaushik

Publisher: Elsevier Science
Year: 2011
Tongue: French
Weight: 329 KB
Volume: 52
Category: Article
ISSN: 0040-4039
DOI: 10.1016/j.tetlet.2010.12.039

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✦ Synopsis

2,4,6-trichlorophenyl)urea (CC-2) Dihydropyrimidones Benzimidazoles Benzothiazoles a b s t r a c t A simple and efficient method for the synthesis of 3,4-dihydropyrimidin-2-(1H)one and benzo[4,5]imidazo/thioazo[1,2-a]pyrimidine derivatives has been described using N,N 0 -dichlorobis(2,4,6-trichlorophenyl)urea (CC-2) as a new reagent. This method is found to be efficient and convenient for the synthesis of pyrimidone and pyrimidine derivatives.

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