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NMR studies on chiral intermediates in the total synthesis of (+)-biotin from D-mannose

✍ Scribed by Wen-xue Chen; Ping Zhang; Fen-er Chen

Publisher: John Wiley and Sons
Year: 2010
Tongue: English
Weight: 138 KB
Volume: 48
Category: Article
ISSN: 0749-1581
DOI: 10.1002/mrc.2619

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✦ Synopsis

Abstract

The chemical structure and stereochemistry of 12 intermediates in the total synthesis of (+)‐biotin starting from D‐mannose as chiral pool were completely assigned using one‐ and two‐dimensional NMR experiments, including 1D selective NOE, DEPT, COSY, HSQC and HMBC. Copyright © 2010 John Wiley & Sons, Ltd.

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