NMR studies of dextran oligomer interactions with model polyphenols

✍ Scribed by Michael P. Williamson; Clare Trevitt; James M. Noble

• Book ID: 102995080
• Publisher: Elsevier Science
• Year: 1995
• Tongue: English
• Weight: 522 KB
• Volume: 266
• Category: Article
• ISSN: 0008-6215
• DOI: 10.1016/0008-6215(94)00273-i

✦ Synopsis

The interaction of bacterial dextrans with polyphenols has been implicated in the formation of dental plaque. Therefore, the NMR spectra of the (1 ~ 6)-a-linked dextran oligomers, (glucose), (n = 1, 2, 3, > 3), have been assigned using two-dimensional methods. Addition of a model polyphenol, propyl gallate, causes only very small changes in the NMR chemical shifts of isomaltose (n~2) and polymers of average length up to 8.2, indicating little apparent binding under these conditions. Titration of dextrans with a model nonhydrolysable proanthocyanidin tannin, ( -)-epicatechin, produced no significant chemical shift changes. These results suggest that the function of bacterial dextrans in modulating the polyphenol content of plaque is at most indirect.