๐”– Bobbio Scriptorium
โœฆ   LIBER   โœฆ

NMR studies of brain 13C-glucose uptake and metabolism: Present status

โœ Scribed by Peter C.M. van Zijl; Doug Rothman

Publisher
Elsevier Science
Year
1995
Tongue
English
Weight
858 KB
Volume
13
Category
Article
ISSN
0730-725X

No coin nor oath required. For personal study only.

โœฆ Synopsis

One of the common features of epilepsy is a change in glucose metabolism at the site of seizure activity during and between seizures. The noninvasive in situ study of glucose transport and metabolism by NMR can potentially provide detailed information about this phenomena. In this short review, we will discuss the principles of 13C-glucose NMR studies of the brain and compare the advantages and disadvantages of this method to those of 18F-deoxyglucose studies using positron emission tomography (PET).

๐Ÿ“œ SIMILAR VOLUMES

NMR measurement of brain oxidative metab
NMR measurement of brain oxidative metabolism in monkeys using 13C-labeled glucose without a 13C radiofrequency channel
โœ Fawzi Boumezbeur; Laurent Besret; Julien Valette; Franรงoise Vaufrey; Pierre-Gill ๐Ÿ“‚ Article ๐Ÿ“… 2004 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 355 KB

We detected glutamate C4 and C3 labeling in the monkey brain during an infusion of [U-13C6]glucose, using a simple 1H PRESS sequence without 13C editing or decoupling. Point-resolved spectroscopy (PRESS) spectra revealed decreases in 12C-bonded protons, and increases in 13C-bonded protons of glutama

Quantitative 13C NMR studies of metaboli
Quantitative 13C NMR studies of metabolic compartmentation in the adult mammalian brain
โœ Fรกtima Cruz; Sebastiรกn Cerdรกn ๐Ÿ“‚ Article ๐Ÿ“… 1999 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 494 KB ๐Ÿ‘ 2 views

We review the information obtained by 13 C NMR methods on the metabolic compartmentation of the adult mammalian brain with emphasis on its quantitative aspects. Classical radiotracer evidence and more recent 13 C NMR results support the presence in the brain of at least two glutamate pools, small an

Detection of [1,6-13C2]-glucose metaboli
Detection of [1,6-13C2]-glucose metabolism in rat brain by in vivo 1H-[13C]-NMR spectroscopy
โœ Robin A. de Graaf; Peter B. Brown; Graeme F. Mason; Douglas L. Rothman; Kevin L. ๐Ÿ“‚ Article ๐Ÿ“… 2002 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 339 KB

## Abstract Localized, waterโ€suppressed ^1^Hโ€[^13^C]โ€NMR spectroscopy was used to detect ^13^Cโ€label accumulation in cerebral metabolites following the intravenous infusion of [1,6โ€^13^C~2~]โ€glucose (Glc). The ^1^Hโ€[^13^C]โ€NMR method, based on adiabatic RF pulses, 3D imageโ€selected in vivo spectros