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NMR structure of the calponin homology domain of human IQGAP1 and its implications for the actin recognition mode

✍ Scribed by Ryo Umemoto; Noritaka Nishida; Shinji Ogino; Ichio Shimada


Publisher
Springer Netherlands
Year
2010
Tongue
English
Weight
631 KB
Volume
48
Category
Article
ISSN
0925-2738

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Calcium- and integrin-binding protein (CIB) binds to the 20-residue alphaIIb cytoplasmic domain of platelet alphaIIbbeta3 integrin. Amino acid sequence similarities with calmodulin (CaM) and calcineurin B (CnB) allowed the construction of homology-based models of calcium-saturated CIB as well as apo