## Abstract The NMR solution structure of a highly stable coiled‐coil IAAL‐E3/K3 has been solved. The E3/K3 coiled‐coil is a 42‐residue __de novo__ designed coiled‐coil comprising three heptad repeats per subunit, stabilized by hydrophobic contacts within the core and electrostatic interactions at
✦ LIBER ✦
NMR structure of a parallel homotrimeric coiled coil
✍ Scribed by Dames, Sonja A.; Kammerer, Richard A.; Wiltscheck, Ronald; Engel, Jürgen; Alexandrescu, Andrei T.
- Book ID
- 109831970
- Publisher
- Nature Publishing Group
- Year
- 1998
- Tongue
- English
- Weight
- 875 KB
- Volume
- 5
- Category
- Article
- ISSN
- 1545-9993
- DOI
- 10.1038/90444
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## Abstract We used the principles governing the selectivity and stability of coiled‐coil segments to design and experimentally test a set of four pairs of parallel coiled‐coil‐forming peptides composed of four heptad repeats. The design was based on maximizing the difference in stability between d