NMR structure-based drug design
โ Scribed by Stephen W. Fesik
- Publisher
- Springer Netherlands
- Year
- 1993
- Tongue
- English
- Weight
- 619 KB
- Volume
- 3
- Category
- Article
- ISSN
- 0925-2738
No coin nor oath required. For personal study only.
๐ SIMILAR VOLUMES
## Abstract Biomolecular NMR spectroscopy has expanded dramatically in recent years and is now a powerful tool for the study of structure, dynamics, and interactions of biomolecules. Previous limitations with respect to molecular size are no longer a primary barrier, and systems as large as 900 kDa
Thymidylate synthase (TS) is a very interesting target in antiproliferative diseases. Its inhibition causes thimineless death of the cells and compounds inhibiting TS are widely used in anticancer therapy. The classical antifolate TS inhibitors are structural analogs of the folate cofactor; they oft