✦ LIBER ✦

NMR Structural Characterization of Peptide Inhibitors Bound to the Hepatitis C Virus NS3 Protease: Design of a New P2 Substituent

✍ Scribed by Goudreau, Nathalie; Cameron, Dale R.; Bonneau, Pierre; Gorys, Vida; Plouffe, Céline; Poirier, Martin; Lamarre, Daniel; Llinas-Brunet, Montse

Book ID: 126981572
Publisher: American Chemical Society
Year: 2004
Tongue: English
Weight: 316 KB
Volume: 47
Category: Article
ISSN: 0022-2623
DOI: 10.1021/jm0303002

No coin nor oath required. For personal study only.

📜 SIMILAR VOLUMES

Optimization of the P‘-Region of Peptide

Optimization of the P‘-Region of Peptide Inhibitors of Hepatitis C Virus NS3/4A Protease

✍ Ingallinella, Paolo; Bianchi, Elisabetta; Ingenito, Raffaele; Koch, Uwe; Steinkü 📂 Article 📅 2000 🏛 American Chemical Society 🌐 English ⚖ 310 KB

The Design and Enzyme-Bound Crystal Stru

The Design and Enzyme-Bound Crystal Structure of Indoline Based Peptidomimetic Inhibitors of Hepatitis C Virus NS3 Protease

✍ Ontoria, Jesus M.; Di Marco, Stefania; Conte, Immacolata; Di Francesco, M. Emili 📂 Article 📅 2004 🏛 American Chemical Society 🌐 English ⚖ 149 KB

Non-Peptidic Small-Molecule Inhibitors o

Non-Peptidic Small-Molecule Inhibitors of the Single-Chain Hepatitis C Virus NS3 Protease/NS4A Cofactor Complex Discovered by Structure-Based NMR Screening

✍ Wyss, Daniel F.; Arasappan, Ashok; Senior, Mary M.; Wang, Yu-Sen; Beyer, Brian M 📂 Article 📅 2004 🏛 American Chemical Society 🌐 English ⚖ 712 KB

The design of a potent inhibitor of the

The design of a potent inhibitor of the hepatitis C virus NS3 protease: BILN 2061—From the NMR tube to the clinic

✍ Youla S. Tsantrizos 📂 Article 📅 2004 🏛 Wiley (John Wiley & Sons) 🌐 English ⚖ 858 KB

## Abstract The virally encoded serine protease NS3/NS4A is essential to the life cycle of the hepatitis C virus (HCV), an important human pathogen causing chronic hepatitis, cirrhosis of the liver, and hepatocellular carcinoma. Until very recently, the design of inhibitors for the HCV NS3 protease

Novel, Potent Phenethylamide Inhibitors

Novel, Potent Phenethylamide Inhibitors of the Hepatitis C Virus (HCV) NS3 Protease: Probing the Role of P2 Aryloxyprolines with Hybrid Structures.

✍ Federica Orvieto; Uwe Koch; Victor G. Matassa; Ester Muraglia 📂 Article 📅 2003 🏛 John Wiley and Sons ⚖ 100 KB 👁 2 views

Unique Composite Active Site of the Hepa

Unique Composite Active Site of the Hepatitis C Virus NS2-3 Protease: a New Opportunity for Antiviral Drug Design

✍ Zucai Suo; Mohd Amir F. Abdullah 📂 Article 📅 2007 🏛 John Wiley and Sons 🌐 English ⚖ 200 KB 👁 1 views