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NMR Reporter Screening for the Detection of High-Affinity Ligands

✍ Scribed by Wolfgang Jahnke; Philipp Floersheim; Christian Ostermeier; Xiaolu Zhang; Rene Hemmig; Konstanze Hurth; Doncho P. Uzunov

Publisher
John Wiley and Sons
Year
2002
Tongue
English
Weight
109 KB
Volume
41
Category
Article
ISSN
0044-8249

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Competition STD NMR for the detection of
Competition STD NMR for the detection of high-affinity ligands and NMR-based screening
✍ Yu-Sen Wang; Dingjiang Liu; Daniel F. Wyss πŸ“‚ Article πŸ“… 2004 πŸ› John Wiley and Sons 🌐 English βš– 241 KB

## Abstract The reported competition STD NMR method combines saturation transfer difference (STD) NMR with competition binding experiments to allow the detection of high‐affinity ligands that undergo slow chemical exchange on the NMR time‐scale. With this technique, the presence of a competing high