✦ LIBER ✦
NMR recognition studies of C·G base pairs by new easily accessible heterobicyclic systems
✍ Scribed by Florence Lecubin; Rachid Benhida; Jean-Louis Fourrey; Jian-Sheng Sun
- Book ID
- 104262446
- Publisher
- Elsevier Science
- Year
- 1999
- Tongue
- French
- Weight
- 250 KB
- Volume
- 40
- Category
- Article
- ISSN
- 0040-4039
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✦ Synopsis
Recognition of DNA duplexes by triplex forming oligonucleotides (TFO) is limited to DNA homopurine sequences. As a first step to overcome this limitation we report here NMR recognition studies of the C.G base pair by new heterocyclic systems, derived from benzimidazole and benzoxazole units bearing an urea donor moiety, designed to bound to the 4-amino group of the cytosine and the 04-and N7-atoms of the guanosine bases, respectively.