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NMR measurement of the degree of oil/water partition of paramagnetic contrast media

โœ Scribed by Laurance D. Hall; Patrick G. Hogan

Publisher
John Wiley and Sons
Year
1988
Tongue
English
Weight
294 KB
Volume
7
Category
Article
ISSN
0740-3194

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โœฆ Synopsis

Magnetic resonance imaging techniques have been used to evaluate the oil/water partition of a series of stable nitroxide free radicals. The degree of partition, K, closely parallels the order of chemical polarity and lipophilicity of these compounds. This method also provides insight into both their nuclear magnetic resonance relaxation characteristics and pharmacokinetics.

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