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NMR investigations of forskolin. Complete assignment of proton and carbon NMR spectra and conformational analysis

✍ Scribed by Herbert Kogler; Hans-Wolfram Fehlhaber

Publisher
John Wiley and Sons
Year
1991
Tongue
English
Weight
524 KB
Volume
29
Category
Article
ISSN
0749-1581

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✦ Synopsis

Abstract

The ^1^H‐ and ^13^C NMR spectra of forskolin have been re‐investigated. Assignments are based exclusively on unambiguous carbon–carbon and carbon‐proton correlations derived from two‐dimensional NMR spectra. Stereo‐specific differentiations were deduced from selective proton NOE measurements and the interpretation of vicinal and long‐range proton‐proton scalar couplings. The proton‐proton distances calculated from proton NOE effects fit best with a flattened boat‐like conformation of ring C, which is different from the conformation of forskolin in the solid state.

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