NMR in cancer. XI. Application of the NMR malignancy index to human gastro-intestinal tumors
✍ Scribed by M. Goldsmith; J. Koutcher; R. Damadian
- Publisher
- John Wiley and Sons
- Year
- 1978
- Tongue
- English
- Weight
- 655 KB
- Volume
- 41
- Category
- Article
- ISSN
- 0008-543X
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✦ Synopsis
One hundred two specimens of human gastro-instestinal tissue taken from eighty-seven individuals were inspected by proton magentic resonance techniques (at 22.5 Megahertz). The purpose of the study was to evaluate the diagnostic capabilities of the nuclear magnetic resonance (NMR) technique with regard to the diagnosis of malignancy. The combination of two NMR parameters (spin-lattice ((TI)) and spin-spin ((Tz)) relaxation times) into a malignancy index yielded complete discrimination between the two populations of tissue. The mean and standard deviations .obtained were 2.004 f 0.342 for normal tissue, and 3.266 f 0.642 for malignant specimens. In addition, the NMR technique indicated that histologically normal tissue taken adjacent to the malignancy was pathologically "involved." Analysis of the electrolyte and water content of such tissues confirms this abnormality. Camtr 41:183-191, 1978. REVIOUS NUCLEAR 'MAGNETIC RESONANCE P (NMR) investigations of human gastro-intestinal tissues have been very limited. 44*'*413*14
I n nearly all cases, the null point spin-lattice relaxation time (T,) was the only NMR parameter determined. Of these studies, the most extensive was an investigation of 19 tumors and 32 normal tissue specimens from the gastro-intestinal tract, made at 100 Megahertz ( M H z ) . ~ The data to be presented below are part of a larger study involving over eight hundred specimens of all types of tissues obtained from over six hundred and fifty individuals. The results of the study on tissues derived from areas other than the gastrointestinal tract are presently being compiled and will be presented for publication in the near future.
The purpose of this large scale study was
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