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NMR-Guided Fragment-Based Approach for the Design of tRNALys3 Ligands

✍ Scribed by Florence Chung; Carine Tisné; Thomas Lecourt; Frédéric Dardel; Laurent Micouin

Publisher
John Wiley and Sons
Year
2007
Tongue
English
Weight
222 KB
Volume
46
Category
Article
ISSN
0044-8249

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## Abstract The reported competition STD NMR method combines saturation transfer difference (STD) NMR with competition binding experiments to allow the detection of high‐affinity ligands that undergo slow chemical exchange on the NMR time‐scale. With this technique, the presence of a competing high