✦ LIBER ✦
NMR evidence for an NH+ …OC intramolecular hydrogen bond in 2-alkyl-3-morpholinopropiophenones—structure of a new elevated high density lipoprotein agent in solution
✍ Scribed by Nicole Cotelle; Philippe Cotelle
- Publisher
- John Wiley and Sons
- Year
- 1991
- Tongue
- English
- Weight
- 415 KB
- Volume
- 29
- Category
- Article
- ISSN
- 0749-1581
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✦ Synopsis
Abstract
7‐[2‐(4‐morpholinomethyl)butanoyl]‐4‐methyl‐2__H__‐1, 4‐benzoxazin‐3 (4__H__)‐one hydrochloride (2a) (a new elevated high density lipoproteins agent) and related compounds have been studied by NMR spectroscopy. Compound 2a exhibits an intramolecular hydrogen bond between the NH^+^ and CO bonds in solvents with low nucleophilicity. These results are confirmed by IR spectroscopy in solution.