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NMR chemical shift substituent effects: 2-α-monosubstituted N,N-diethylacetamides

✍ Scribed by Marcos A. P. Martins; Roberto Rittner

Publisher
John Wiley and Sons
Year
1980
Tongue
English
Weight
490 KB
Volume
14
Category
Article
ISSN
0749-1581

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✦ Synopsis

Abstract

^1^H NMR chemical shifts for some α‐hetero‐substituted N,N‐diethylacetamides were recorded. The resonance assignments for the syn‐ and anti‐methylene and ‐methyl protons have been made unambiguously through their aromatic solvent induced shifts and are opposed to the literture assignments for the N‐methylene protons. An empirical relationship between the Charton polar (σ~L~) and steric (V) parameters and the α‐methylene proton resonances was found. The N‐methylene proton chemical shifts also showed a qualitative dependence on the α‐substituent electronegativity, while the N‐ethyl methyl proton chemical shifts were related to the α‐substituent steric effects. The Paulsen and Todt anisotropic model and the more populated rotamers proposed seem to explain the results very well.

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